Hyperhidrosis is a common medical condition characterized by excessive sweating. A recent systematic literature review investigated the efficacy and safety of several common Hyperhidrosis therapies. Hyperhidrosis is a chronic autonomic disorder characterized by excessive sweating that affects approximately 4.8% of the United States population. The condition can significantly reduce the quality of life by negatively
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Despite the availability of chemotherapeutic agents for the treatment of acute lymphoblastic leukemia, some patients won’t respond to the drugs or experience relapse. A phase 3 clinical trial examined the safety profile of inotuzumabozogazamin, a novel chemotherapeutic drug which has a potential to be used for relapsed and refractory acute lymphoblastic leukemia. There are many
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An analysis of germline mutation status predicting therapy response results from the GeparSixto trial looked into the efficacy of the treatment regimen for patients with triple-negative breast cancer. Triple-negative breast cancer (TNBC) patients carrying a germline mutation demonstrate better pathological complete response (pCR) and disease-free survival (DFS) rates under the anthracycline, taxane, and bevacizumab regimen.
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A group of researchers compared the biosimilar monoclonal antibody CT-P10 to the currently used rituximab in the treatment of follicular lymphoma. Non-Hodgkin Lymphoma (NHL) is a blood cancer characterized by the aberrant growth and multiplication of white blood cells (lymphocytes). Cancerous lymphocytes can migrate to and from tumors in different parts of the body, including
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Oxidative stress has negative effects in the intestines and one group recently studied whether arginine supplementation can alleviate these effects, using an animal model. The study demonstrates that oxidative stress decreases arginine levels and increases inflammation, whereas the addition of arginine to the diet reverses these outcomes. Free radicals are chemically reactive molecules that are
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Tau proteins might be associated with dementia (including Alzheimer’s disease) as well as mild cognitive impairment and cognitive decline. The current study found that higher levels of total tau in blood plasma were significantly associated with cognitive decline. Dementia represents a broad category of neurological diseases that cause gradual cognitive decline over time. The most
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Surgical tumor removal followed by stereotactic radiosurgery significantly lowers rates of tumor recurrence compared with tumor removal alone. Cancer metastases to the brain are a major healthcare burden. For single metastases, surgical removal of the tumor followed by whole brain radiotherapy (WBRT) is the standard of care and has been shown to improve survival compared
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Being diagnosed with pregnancy induced hypertension (HTN) may result in the development of post-pregnancy hypertension in the years following the delivery. Hypertension (HTN), or commonly high blood pressure, is a medical condition where there is persistent elevation in the blood pressure in the arteries. If this persists long-term the body may suffer direct damage in
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Complementary therapies are an appealing option for many patients with chronic disease. A recent study suggests supplementation with mulberry leaf extract may help decrease blood glucose levels after meals in patients with type 2 diabetes. Mulberry leaves have a history of anecdotal use in Asia to treat glucose irregularities and studies in diabetic rats have
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Myocardial infarction (heart attack) is often treated with beta-blockers in the long-term, but the effectiveness of this medication is not well studied in patients without heart failure. Dondo and colleagues recently showed that there is no benefit to using beta-blockers in patients without heart failure. Myocardial infarction, or heart attack, happens when the heart stops
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A recent study reports an association between low levels of vitamin A (Retinol), vitamin E and retinol binding protein (RBP4) and a poor prognosis for renal cell carcinoma. Renal cell carcinoma is the most prevalent kidney cancer in adults, and it refers to various tumors in the nephron tissue (kidney tubular structures mediating transport of
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An aimed to investigate whether the consumption of sweetened beverages was linked with diabetes mellitus risk factors. It was concluded that sugar-sweetened and artificially sweetened beverages were associated with, respectively, 43% and 21% increased risks of developing diabetes mellitus. Diabetes mellitus (DM) is an increasing burden on the public health system due to the widespread
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Recently, the end of life care experienced by older adult individuals has sparked interest and observations have been made to identify the potential risk factors for aggressive care along with an evaluation of the cost. This highlights the need to keep families informed about what to expect when an older adult in their midst has
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Researchers have systematically evaluated antibiotic use in patients and concluded that antibiotics are still being overused. Adverse drug effects are any injuries or negative reactions caused by taking a medication and are common even in everyday medications such as antibiotics. Recent recommendations have advised fewer antibiotic prescriptions, however, research has shown that as much as
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Attention-deficit/hyperactivity disorder (ADHD) is a well-known problem in children, adolescents and adults, but the long-term effects of stimulants such as Ritalin during childhood when the brain is still developing remain unclear. A recent study showed that levels of ϒ-amino butyric acid (GABA) in the adult prefrontal cortex were decreased in patients who had begun stimulant
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Research examines the prevalence of abuse in older adults globally and in turn highlight the risk and need for increased protection services in this regard. Elderly abuse continues to be a growing problem. In 2015 there were an estimated 901 million older adults, or adults over the age of 65, globally. Psychological abuse is the
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A recent article, published in The American Journal of Clinical Nutrition, investigates how the metabolism of eicosapentaenoic acid (EPA) and arachidonic acid (AA) changes with age. There are significant metabolic and biological changes that occur with progressing age. These changes must be taken into consideration to maintain a healthy and balanced nutritional intake. For instance,
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A recently published report shows that high intake of the dietary omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid could increase your risk for colorectal adenoma (precancerous polyps that can develop into cancer). Colorectal cancer is the second most common type of cancer, accounting for 13% of all cancers.1 With improved endoscopic screening for adenomas, the
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A new study has found that dietary protein and fat intake can influence, and indeed enhance the FTO gene-linked risk for obesity in children.   Obesity is a complex trait that is influenced by the interplay of genetic, socioeconomic, cultural, psychological, and lifestyle-related factors. Studies have identified more than 430 genes that are associated with
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Basal levels of steroid hormones dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) are not significantly different in patients with posttraumatic stress disorder compared with non-trauma-exposed subjects. Approximately 10% of individuals exposed to traumatic events develop posttraumatic stress disorder (PTSD). Symptoms of PTSD include re-experiencing the traumatic event, negative cognitive and mood changes, and hyper-reactivity. To further
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Scientists compared three anti-epileptic drugs including one branded Lamotrigine and two lamotrigine-generic drugs and found them to be bioequivalent. Now we know: branded and generic drugs can be substituted with confidence. It is estimated that nearly 80% prescriptions filled in the US are for generic drugs. The US Food and Drug Administration (FDA) requires that
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