Drugs

Scientists have developed a computer capable of determining the lowest energy state of three compounds; bring them closer to using quantum computers for the discovery and development of new drugs. The advent of powerful computers has allowed for substantial progress in fields like statistics, bioinformatics, and medicine. However, classical computers are limited in their progressing
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A new study reports that bacterial mutation rates are significantly higher under crowded conditions and offers insights which could help develop methods to counter antibiotic resistance. Mutations, or changes in the DNA sequence, create genetic variations which can be beneficial or deleterious and are essential for the evolution of organisms. In fact, genetic mutations are
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Antibiotic resistance is a major problem in healthcare. It is important to develop the most effective antibiotic prescription strategy. A recent study investigated the effectiveness of antibiotics in patients with acute uncomplicated respiratory tract infections. Acute respiratory tract infections are one of the most common complications managed by primary care physicians. These patients most commonly
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Statistics show that in 2015, the number of practicing doctors above the age of 65 was 23% of all health professionals. This percentage has increased by more than 374% since the year 1975. More than ever, we are left to wonder: what is the appropriate physician retirement age? There is concern regarding the ability of
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Vasodilatory shock resistant to traditional treatment with vasopressors is associated with a high mortality rate A recent study published in The New England Journal of Medicine sets out to investigate the effects of angiotensin II as a treatment. Shock can be a fatal syndrome as a result of decreased perfusion of vital organs which leads
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In a 2017 study, researchers explored the association between single nucleotide polymorphisms of the C-reactive protein gene and age-related macular degeneration. The findings suggest that C-reactive protein does not cause macular degeneration. Associations have been drawn between high levels of the inflammatory biomarker C-reactive protein (CRP) and age-related macular degeneration (AMD) – deterioration of the
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Gonorrhea is one of the most common STI (sexually transmitted infections) worldwide. In 2016, the Global Antibiotic Research and Development Partnership (GARDP) was developed to address the concerns regarding the emergence of multidrug-resistant gonorrhea and the need for new treatments. Gonorrhea, caused by Neisseria gonorrheae bacteria is one of the most common STIs (sexually transmitted
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Leprosy is a worldwide disease. Unfortunately, efforts to eradicate this debilitating illness have stalled. This overview calls for a worldwide coalition towards a zero-case strategy. Leprosy, a bacterial disease, is a major cause of peripheral neuropathy leading to disability. Leprosy remains in over 100 countries and the battle to eliminate this disease has been fought
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Liver disease is a common cause of premature death in the UK. Recently, The Lancet Commission on Liver Disease highlighted the financial impact liver disease places on the national healthcare system and businesses, and suggested strategies to reduce these burdens. The negative impacts of liver disease on citizens under the age of 65 in the
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Acute kidney injury is a common condition seen by clinicians in different settings. An article published in the Clinical Kidney Journal this 2017 provided an overview of the current diagnosis and clinical management of this condition. An article published in the Clinical Kidney Journal this 2017 provided an overview of the current diagnostic methods and
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Community acquired pneumonia (CAP) is a common cause of morbidity and mortality worldwide. Recent advances in research and technology have helped in the understanding of the disease which in turn aids treatment and management. Community acquired pneumonia is one of the main causes of hospital admissions and healthcare professionals encounter community acquired pneumonia in different
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Researchers have systematically evaluated antibiotic use in patients and concluded that antibiotics are still being overused. Adverse drug effects are any injuries or negative reactions caused by taking a medication and are common even in everyday medications such as antibiotics. Recent recommendations have advised fewer antibiotic prescriptions, however, research has shown that as much as
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Scientists compared three anti-epileptic drugs including one branded Lamotrigine and two lamotrigine-generic drugs and found them to be bioequivalent. Now we know: branded and generic drugs can be substituted with confidence. It is estimated that nearly 80% prescriptions filled in the US are for generic drugs. The US Food and Drug Administration (FDA) requires that
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Researchers investigated the effect of age and proton pump inhibitors on aspirin-associated bleeding in cardiovascular patients. The study found that use of proton pump inhibitors reduces the risk and severity of bleeding in patients 75 and older. Though antiplatelet therapies such as aspirin are routinely prescribed for the prevention of recurring cardiovascular events in older
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Viral infection with the hepatitis A has a low prevalence in Europe; however, a retrospective analysis found that while overall hepatitis A prevalence is decreasing, some regions still have a moderate to high risk of hepatitis A infection. Hepatitis A is a disease caused by viral infection of the liver by the hepatitis A virus.
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Chikungunya virus is a mosquito-borne virus for which recent outbreaks in human populations have drawn a lot of interest from the scientific community. Luckily, a group of investigators recently reported the development of a monoclonal antibody with therapeutic potential in a macaque monkey model of the disease. Chikungunya virus (CHIKV) can be transmitted to humans
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Urinary tract infection (UTI) related to urinary catheter use can cause many problems in nursing home residents. A USA nationwide project to improve care in this area successfully reduced the number of catheter-associated UTIs.   A urinary catheter is a small flexible tube inserted via the urethra into the bladder to drain urine. It is
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Antibiotic use for respiratory tract infections is the mainstay therapy in primary care but a recent study shows that hospital reconsultations with symptoms of lower respiratory tract infections (LRTI) can be significantly reduced with delayed antibiotic prescription.   Infections of the respiratory tract are a regular reason for primary care consultations and patients often present
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A phase two randomized controlled trial determined the role of immune plasma in treating patients diagnosed with severe influenza and exhibiting respiratory compromise. A pandemic influenza outbreak is a serious international concern. Immediate containment of the disease is necessary, along with fast implementation of preventative measures. Plasma treatment has been identified as a solution for
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A meta-analysis study published in JAMA Pediatrics investigated the effectiveness and safety of antibiotic treatment over surgical intervention in children with uncomplicated appendicitis.   The appendix is a blind-ended tube connected to the cecum, the initial part of the large intestine. Appendicitis is an inflammation of the appendix, which is acute and painful condition felt at the right
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Clinical trial data support the administration of antibiotics within 60 minutes before surgery for prevention of infection.   Surgical site infections (SSIs) are the most common hospital-acquired infections in surgical patients. To prevent such infections, the World Health Organization (WHO)recommends antibiotics be given within an hour of surgical incision. Called surgical antimicrobial prophylaxis (SAP), these
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In a 2017 study, researchers investigated the use of antivirals in children hospitalized for influenza. Rates of prescription of anti-influenza medication in children were found to be below recommended levels and varied significantly between hospitals.   The recommended treatment for children hospitalized due to infection with influenza viruses, especially children with conditions which may increase
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