Clinical Trials & Research

An episodic migraine is a debilitating headache disorder with few effective and safe preventative treatments available. Researchers in this study conducted a trial on erenumab, to determine its effectiveness in providing relief for people suffering from episodic migraines. Migraines are defined as a debilitating headache disorder that manifests as a throbbing headache which can last
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Researchers at Spark Therapeutics and Pfizer tested the safety and efficacy of a new hemophilia gene therapy vector for the treatment of hemophilia B. The body’s ability to stop bleeding and repair damaged blood vessels depends heavily upon a variety of clot-forming enzymes. Deficiency in one such enzyme, coagulation factor IX, results in the development
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Scientists are investigating the effectiveness of using galcanezumab to prevent migraines, a monoclonal antibody that targets the proteins involved in migraine pathophysiology. Migraines are chronic, debilitating headaches that can last a few hours or up to a few days. The cost to migraine sufferers is quite high when considering absenteeism from school or work and
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In a recent multinational clinical trial, researchers evaluated the effectiveness of two fremanezumab regimens for chronic migraine prevention. The transmission of pain signals during migraines is thought to be carried out in part by the release of calcitonin gene-related peptide (CGRP) from one nerve and reception by the next. Early trials have shown that fremanezumab,
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A recent study evaluated the effectiveness of using a subcutaneous injection to prevent postherpetic neuralgia, a common complication of shingles. Chickenpox is a common childhood infection caused by the herpes zoster virus. However, once the rash caused by the virus has cleared up, the virus can lay dormant for years. Later in life, or due
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A clinical trial involving patients with heart diseases has revealed new dimensions of the role of anti-inflammatory medications in preventing heart attacks. Like many diseases, it’s been proven that inflammation can be an underlying predisposing factor for cardiovascular diseases including heart attacks and strokes. Investigations about the role of inflammatory pathways in developing cardiovascular disease
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Researchers test the safety and efficacy of a natural anti-fungal treatment derived from spirulina to treat severe fungal infections of the skin and nails. Superficial fungal infections of the hair, skin, or nails, also referred to dermatophytosis, affects about a quarter of the world’s population. Topical anti-fungal treatment creams can be used to treat dermatophytosis,
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The NIH has amended its definition of clinical trials to include brain studies, introducing new regulations considered unnecessary by many researchers. The National Institutes of Health (NIH) has implemented its controversial decision to broaden the scope of clinical trials to include cognitive and behavioural studies. This change, which has been in discussion since at least
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Researchers determine whether oral corticosteroids, such as prednisolone,  reduce symptom duration or severity for acute lower respiratory tract infection in non-asthmatic adults. Acute lower respiratory tract infection (LRTI), defined as an acute cough with at least one of the symptoms of sputum, chest pain, shortness of breath, and wheezing is one of the most common
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Behavioural intervention can help decrease psychological distress among women with a history of gender-based violence. A clinical trial determines the effectiveness of a community-taught behavioral treatment on psychological distress. Gender-based violence toward women has been linked to increased mental stress and psychological morbidity in low and middle-income countries worldwide, specifically in urban Kenya. The treatment
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Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
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Despite the availability of chemotherapeutic agents for the treatment of acute lymphoblastic leukemia, some patients won’t respond to the drugs or experience relapse. A phase 3 clinical trial examined the safety profile of inotuzumabozogazamin, a novel chemotherapeutic drug which has a potential to be used for relapsed and refractory acute lymphoblastic leukemia. There are many
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In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms. Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound effects on
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence. Stress urinary incontinence, or
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The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS). The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence by
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Cardiovascular diseases are currently the leading cause of mortality worldwide. A group of researchers led by Jeffrey Cohen introduced a new method of preventing heart attacks using photosynthetic bacteria. According to the World Health Organization, cardiovascular diseases are the leading cause of mortality worldwide. Different strategies are being studied to improve
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A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence. Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
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A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not. Triggered
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A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron deficiency
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A recent New England Journal of Medicine article reports that Rivaroxaban has greater efficacy and more acceptable side effects than Aspirin in patients with recurrent venous thromboembolisms. Thrombose, the formation of blood clots, is a medical emergency that requires prompt medical attention. Three factors, commonly referred to as the Virchow triad, contribute to the formation
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Tuberculosis is a communicable respiratory disease. A group of researchers led by Maeve Lalor conducted a cohort study to determine household transmission of tuberculosis in England by combining epidemiologic and molecular strain typing data. Tuberculosis is a communicable respiratory disease prevalent in some third world countries. In first world countries where the prevalence of this
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