Advances in nanotechnology may soon give rise to an innovative way in the treatment of cancer: drilling through the membrane and destroying the cancer cells. The basic tenet of cancer treatment is its total eradication from the human body, but the aggressive and invasive nature of malignancies complicate and in many instances prevent this from
Personalized medicine is the future of cancer therapy. A recent report shows that one lab has successfully tested the zebrafish cancer response and its potential to be used to personalize patient treatment. Cancer is a heterogeneous disease. Not only are different types of cancers unique from one another, like brain cancer and breast cancer, but
A new study investigates a possible link between variants of the vitamin D receptor gene and the risk of developing nonmelanoma skin cancer. Nonmelanoma skin cancer refers to all forms of skin cancer that develops in the lower parts of the outer epidermis, including basal cells (basal cell carcinoma) and squamous cells (squamous cell carcinoma).
With millions of cancer-related ER visits per year, and cancer rates anticipated to double by 2040, healthcare facilities will need to thoughtfully prepare to maintain operational standards. Emergency departments are notoriously overburdened, resulting in huge inefficiencies. Most people have a personal story of waiting for hours at “emergency” clinics overwhelmed with people requiring immediate care.
A recently published study set out to discover whether an immune signature can be used to provide a reliable prognosis for patients with early-stage lung cancer. Of all lung cancer cases, 85% are attributable to non-small cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. Many patients with early-stage lung cancer do not
Durvalumab is one of a group of new cancer drugs called immune “checkpoint inhibitors”. It is undergoing clinical trials and the initial findings of its use in advanced bladder cancer have been reported in a recent study. The immune system is made up of organs, cells, and substances within the body which helps to protect
A recent study determines whether the prevalence of neuropathic pain in women following breast cancer treatment is higher compared with those in other cancer types. Neuropathic pain is pain that is caused by damaged or dysfunctional nerve cells, which results in pain signals being sent to the brain. It is associated with a host of
This is the first reported instance of restoration of hair color in response to anti-PD1/anti-PD-L1lung cancer treatment therapy. Programmed cell death protein 1 (PD-1) is a protein present on the surface of a number of cells of the immune system, such asCD4+ and CD8+ T cells, B cells, monocytes, natural killer cells, and dendritic cells.1 As
A recent study investigated gait characteristics in pediatric acute lymphoblastic leukemia (ALL) patients with chemotherapy-induced peripheral neuropathy (CIPN). Childhood acute lymphoblastic leukemia (ALL) is characterized by the excessive production of immature lymphocytes which are incapable of fighting infections. Although recent advances in chemotherapeutics have increased survival rates to almost 90%, these drugs are often accompanied
Olaparib (Lynparza) is a treatment for advanced ovarian cancer in patients carrying inherited mutations in the BRCA gene. A study compares olaparib with standard drugs for the treatment of metastatic breast cancer in patients with inherited BRCA mutation. Mutations in BRCA1 and BRCA2, the tumor suppressor genes that code for proteins involved in DNA
Comparing the effectiveness of an immunotherapy inhibitor, nivolumab, with platinum-based chemotherapy may help oncologists determine which drug is most beneficial as a first line treatment for patients with advanced or recurrent non-small-cell lung cancer. As its name suggests, platinum-based chemotherapy contains complexes of the metal platinum, which can bring along an entourage of symptoms.
Researchers determine whether age is an important factor in the spread of thin melanoma in the lymph nodes. Melanoma is a cancer of the skin. It can be classified into three divisions based on the thickness of the cancer: thin melanoma (less than 1mm), intermediate melanoma (1mm to 4mm), and thick melanoma (greater than 4mm).
According to recent studies, ductal carcinoma in situ, a non-invasive benign tumour of the breast, is over-diagnosed and therefore overtreated. An unfortunate reaction to overtreatment of benign breast tumours might be a decrease of the active surveillance of the breast tissue which causes patients to be underdiagnosed for invasive ductal carcinoma. Tumours can either be
The CRISPR-Cas9 screening method has identified the genes that play a role in the body’s immune response to tumors. This important discovery will help to improve the results of cancer immunotherapy. Cancer cells are known to often contain genetic mutations. However, other non-cancerous cells within the body may also contain mutations which can either hinder
Recent clinical trials have provided evidence that treating metastatic prostate cancer with a combination of abiraterone and androgen-depravation therapy (ADT) significantly improves the survival rate of patients with metastatic or locally advanced prostate cancer. Approximately one in seven men worldwide are diagnosed with prostate cancer at least once in their life, and so ensuring the
Over 50 years ago scientists accidentally discovered tamoxifen, the standard adjuvant treatment used for the past three decades to reduce the risk of recurrence in breast cancer patients. However, with advances in research comes new therapeutics and the question arises whether tamoxifen is still the best drug available to help reduce breast cancer recurrence? Tamoxifen
A phase 2b clinical trial testing the efficacy of the anticancer drug tremelimumab for the treatment of relapsed malignant mesothelioma found that the drug may be ineffective in treating the disease. Malignant mesothelioma is a rare and aggressive cancer of the pleural (found in the lung) or peritoneal (found in the abdomen)or pericardial (found in
A recent study reports that a high-fiber diet during radiation therapy for pelvic cancer helps reduce gastrointestinal radiation toxicity both immediately and over the long term compared to habitual fiber intake. This finding contravenes existing practice that recommends low-fiber diets to people undergoing pelvic radiation therapy. Radiation therapy is commonly used to treat abdominal and
An analysis of germline mutation status predicting therapy response results from the GeparSixto trial looked into the efficacy of the treatment regimen for patients with triple-negative breast cancer. Triple-negative breast cancer (TNBC) patients carrying a germline mutation demonstrate better pathological complete response (pCR) and disease-free survival (DFS) rates under the anthracycline, taxane, and bevacizumab regimen.
A group of researchers compared the biosimilar monoclonal antibody CT-P10 to the currently used rituximab in the treatment of follicular lymphoma. Non-Hodgkin Lymphoma (NHL) is a blood cancer characterized by the aberrant growth and multiplication of white blood cells (lymphocytes). Cancerous lymphocytes can migrate to and from tumors in different parts of the body, including
Surgical tumor removal followed by stereotactic radiosurgery significantly lowers rates of tumor recurrence compared with tumor removal alone. Cancer metastases to the brain are a major healthcare burden. For single metastases, surgical removal of the tumor followed by whole brain radiotherapy (WBRT) is the standard of care and has been shown to improve survival compared
A recent study reports an association between low levels of vitamin A (Retinol), vitamin E and retinol binding protein (RBP4) and a poor prognosis for renal cell carcinoma. Renal cell carcinoma is the most prevalent kidney cancer in adults, and it refers to various tumors in the nephron tissue (kidney tubular structures mediating transport of
A recently published report shows that high intake of the dietary omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid could increase your risk for colorectal adenoma (precancerous polyps that can develop into cancer). Colorectal cancer is the second most common type of cancer, accounting for 13% of all cancers.1 With improved endoscopic screening for adenomas, the
A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer. Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with locally
Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection. Cervical cancer, caused by the human
Caring for patients with cancer can be a stressful situation for caregivers. In a study published in Cancer, researchers found out that depressive symptoms among caregivers were associated with the decline in their physical health. As a caregiver caring for patients with cancer, the entire situation can be very mentally challenging. The effects of stress
Women with genetic mutations in the BRCA1 and BRCA2 genes and 2 or more close relatives with breast cancer are almost twice as likely to develop breast cancer than those with no family history of the disease. BRCA1 and BRCA2 are human genes that produce proteins involved in tumor suppression. Inherited mutations in BRCA1 and
A recent study assessed the potential role of the fecal immunochemical test for colorectal cancer screening in at risk patients. Colorectal cancer (CRC) develops in the colon or rectum, and it accounts for 10% of cancer-related mortality in western world1. Most colorectal cancer begins as a polyp then grow into advanced neoplasia(AN) and, ultimately, cancer.