Cancer

With millions of cancer-related ER visits per year, and cancer rates anticipated to double by 2040, healthcare facilities will need to thoughtfully prepare to maintain operational standards. Emergency departments are notoriously overburdened, resulting in huge inefficiencies. Most people have a personal story of waiting for hours at “emergency” clinics overwhelmed with people requiring immediate care.
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A recently published study set out to discover whether an immune signature can be used to provide a reliable prognosis for patients with early-stage lung cancer. Of all lung cancer cases, 85% are attributable to non-small cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. Many patients with early-stage lung cancer do not
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A recent study determines whether the prevalence of neuropathic pain in women following breast cancer treatment is higher compared with those in other cancer types. Neuropathic pain is pain that is caused by damaged or dysfunctional nerve cells, which results in pain signals being sent to the brain. It is associated with a host of
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A recent study investigated gait characteristics in pediatric acute lymphoblastic leukemia (ALL) patients with chemotherapy-induced peripheral neuropathy (CIPN). Childhood acute lymphoblastic leukemia (ALL) is characterized by the excessive production of immature lymphocytes which are incapable of fighting infections. Although recent advances in chemotherapeutics have increased survival rates to almost 90%, these drugs are often accompanied
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  Olaparib (Lynparza) is a treatment for advanced ovarian cancer in patients carrying inherited mutations in the BRCA gene. A study compares olaparib with standard drugs for the treatment of metastatic breast cancer in patients with inherited BRCA mutation. Mutations in BRCA1 and BRCA2, the tumor suppressor genes that code for proteins involved in DNA
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  Comparing the effectiveness of an immunotherapy inhibitor, nivolumab, with platinum-based chemotherapy may help oncologists determine which drug is most beneficial as a first line treatment for patients with advanced or recurrent non-small-cell lung cancer. As its name suggests, platinum-based chemotherapy contains complexes of the metal platinum, which can bring along an entourage of symptoms.
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According to recent studies, ductal carcinoma in situ, a non-invasive benign tumour of the breast, is over-diagnosed and therefore overtreated. An unfortunate reaction to overtreatment of benign breast tumours might be a decrease of the active surveillance of the breast tissue which causes patients to be underdiagnosed for invasive ductal carcinoma. Tumours can either be
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The CRISPR-Cas9 screening method has identified the genes that play a role in the body’s immune response to tumors. This important discovery will help to improve the results of cancer immunotherapy. Cancer cells are known to often contain genetic mutations. However, other non-cancerous cells within the body may also contain mutations which can either hinder
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Recent clinical trials have provided evidence that treating metastatic prostate cancer with a combination of abiraterone and androgen-depravation therapy (ADT) significantly improves the survival rate of patients with metastatic or locally advanced prostate cancer. Approximately one in seven men worldwide are diagnosed with prostate cancer at least once in their life, and so ensuring the
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Over 50 years ago scientists accidentally discovered tamoxifen, the standard adjuvant treatment used for the past three decades to reduce the risk of recurrence in breast cancer patients. However, with advances in research comes new therapeutics and the question arises whether tamoxifen is still the best drug available to help reduce breast cancer recurrence? Tamoxifen
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A recent study reports that a high-fiber diet during radiation therapy for pelvic cancer helps reduce gastrointestinal radiation toxicity both immediately and over the long term compared to habitual fiber intake. This finding contravenes existing practice that recommends low-fiber diets to people undergoing pelvic radiation therapy. Radiation therapy is commonly used to treat abdominal and
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An analysis of germline mutation status predicting therapy response results from the GeparSixto trial looked into the efficacy of the treatment regimen for patients with triple-negative breast cancer. Triple-negative breast cancer (TNBC) patients carrying a germline mutation demonstrate better pathological complete response (pCR) and disease-free survival (DFS) rates under the anthracycline, taxane, and bevacizumab regimen.
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A group of researchers compared the biosimilar monoclonal antibody CT-P10 to the currently used rituximab in the treatment of follicular lymphoma. Non-Hodgkin Lymphoma (NHL) is a blood cancer characterized by the aberrant growth and multiplication of white blood cells (lymphocytes). Cancerous lymphocytes can migrate to and from tumors in different parts of the body, including
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Surgical tumor removal followed by stereotactic radiosurgery significantly lowers rates of tumor recurrence compared with tumor removal alone. Cancer metastases to the brain are a major healthcare burden. For single metastases, surgical removal of the tumor followed by whole brain radiotherapy (WBRT) is the standard of care and has been shown to improve survival compared
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A recent study reports an association between low levels of vitamin A (Retinol), vitamin E and retinol binding protein (RBP4) and a poor prognosis for renal cell carcinoma. Renal cell carcinoma is the most prevalent kidney cancer in adults, and it refers to various tumors in the nephron tissue (kidney tubular structures mediating transport of
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A recently published report shows that high intake of the dietary omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid could increase your risk for colorectal adenoma (precancerous polyps that can develop into cancer). Colorectal cancer is the second most common type of cancer, accounting for 13% of all cancers.1 With improved endoscopic screening for adenomas, the
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A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer. Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with locally
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Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection. Cervical cancer, caused by the human
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