Eicosapentaenoic Acid Metabolism Changes With Age

Aging


A recent article, published in The American Journal of Clinical Nutrition, investigates how the metabolism of eicosapentaenoic acid (EPA) and arachidonic acid (AA) changes with age.

There are significant metabolic and biological changes that occur with progressing age. These changes must be taken into consideration to maintain a healthy and balanced nutritional intake. For instance, studies have shown that the metabolism of polyunsaturated fatty acids can significantly differ depending on the type of fatty acid and its source, as well as a person’s age. Acknowledging and thoroughly understanding the changes that accompany an aging body is important to ensure proper intake of nutrients.

A recent article, published in The American Journal of Clinical Nutrition, investigated the metabolism of two important fatty acids, eicosapentaenoic acid (EPA) and arachidonic acid (AA), in six healthy young men (aged 18 to 30 years) and six older men (over the age of 70 years). Eicosapentaenoic acid is a precursor to docosahexaenoic acid (DPA), the important omega-3 fatty acid that is a primary structural component of the human brain, retina and skin.

Participants were given a single 35 mg dose of eicosapentaenoic acid or 50 mg of arachidonic acid at the beginning of each study period. Blood and breath samples were collected at baseline (before ingestion of eicosapentaenoic acid or arachidonic acid) and thereafter at various time points over the course of the study period, which lasted a total of 28-days. The ingested fatty acids were labeled with a heavy isotope of carbon, allowing researchers to track their plasma levels and their conversion into other fatty acids or carbon dioxide.

The authors discovered that arachidonic acid metabolism was not significantly different between younger and older men. More precisely, arachidonic acid’s plasma peak levels, half-life, and conversion into carbon dioxide (B-oxidation) were similar between both age groups. This contrasts with previous epidemiological studies that discovered elevated levels of arachidonic acid with increasing age. Therefore, further studies are warranted to further investigate any association between arachidonic acid metabolism and age.

In contrast to arachidonic acid, the metabolism of eicosapentaenoic acid was slightly, but significantly, different between older and younger men. The authors had previously shown that DHA levels were significantly (5-fold) higher in older men, compared to young men. A similar trend was discovered for eicosapentaenoic acid levels, where older men had a significantly higher (2-fold) level of eicosapentaenoic acid than younger men after ingestion. Moreover, the amount of DHA converted from eicosapentaenoic acid was higher in older men.

In conclusion, the current study highlights that the metabolism of certain nutrients, like eicosapentaenoic acid, may be altered with progressing age, and care must be taken when establishing dietary habits.

Written by Haisam Shah, BSc

Citation

Léveillé, P., Chouinard-Watkins, R., Windust, A., Lawrence, P., Cunnane, S. C., Brenna, J. T., & Plourde, M. (2017). Metabolism of uniformly labeled 13C-eicosapentaenoic acid and 13C-arachidonic acid in young and old men. The American Journal of Clinical Nutrition, ajcn154708.

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