Month: September 2017

  Olaparib (Lynparza) is a treatment for advanced ovarian cancer in patients carrying inherited mutations in the BRCA gene. A study compares olaparib with standard drugs for the treatment of metastatic breast cancer in patients with inherited BRCA mutation. Mutations in BRCA1 and BRCA2, the tumor suppressor genes that code for proteins involved in DNA
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  Comparing the effectiveness of an immunotherapy inhibitor, nivolumab, with platinum-based chemotherapy may help oncologists determine which drug is most beneficial as a first line treatment for patients with advanced or recurrent non-small-cell lung cancer. As its name suggests, platinum-based chemotherapy contains complexes of the metal platinum, which can bring along an entourage of symptoms.
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The essential oils found in Curcuma herbs have many uses. Researchers in China determine the composition and therapeutic activity of Curcuma herb essential oils extracted from four Curcuma herb species. Curcuma herbs have been used in Southeast Asia for thousands of years for their claimed antioxidative, antimicrobial, anti-inflammatory, and cytotoxic effects. the chemical composition of
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Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
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A recent analysis of geriatric patients hospitalized through emergency departments shows that proper geriatric assessments of older patients may reduce admission rates. A recent article published in Age and Ageing by the Oxford University Press reviewed the evidence behind performing comprehensive geriatric assessments (CGA) for more elderly patients that present at the emergency department. The
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Statistics show that in 2015, the number of practicing doctors above the age of 65 was 23% of all health professionals. This percentage has increased by more than 374% since the year 1975. More than ever, we are left to wonder: what is the appropriate physician retirement age? There is concern regarding the ability of
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In a recent study, researchers sought to identify proteins important for the anti-neural plasticity effects of histone deacetylase 2 (Hdac2) in Alzheimer’s disease. How Cells Control Gene Activity  Acetylation is one method by which cells control gene activity by the addition or removal of acetyl groups. Acetylation is performed by enzymes called acetyltransferases on histone
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Vasodilatory shock resistant to traditional treatment with vasopressors is associated with a high mortality rate A recent study published in The New England Journal of Medicine sets out to investigate the effects of angiotensin II as a treatment. Shock can be a fatal syndrome as a result of decreased perfusion of vital organs which leads
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Attitudes toward breastfeeding have a chequered past despite the many positive health benefits it provides and its association with children’s cognitive development. Currently, the UK has one of the lowest rates of breastfeeding in the world, mainly due to social attitudes. Although policies promoting breastfeeding have been introduced in the UK, it appears that greater
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According to recent studies, ductal carcinoma in situ, a non-invasive benign tumour of the breast, is over-diagnosed and therefore overtreated. An unfortunate reaction to overtreatment of benign breast tumours might be a decrease of the active surveillance of the breast tissue which causes patients to be underdiagnosed for invasive ductal carcinoma. Tumours can either be
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The CRISPR-Cas9 screening method has identified the genes that play a role in the body’s immune response to tumors. This important discovery will help to improve the results of cancer immunotherapy. Cancer cells are known to often contain genetic mutations. However, other non-cancerous cells within the body may also contain mutations which can either hinder
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Genome-wide association studies for many neurological disorders have limiting factors that cause the inability to draw significant clinical outcomes. Recently, studies have overcome these limitations for three neurological disorders, including multiple sclerosis, Alzheimer’s, and Huntington’s disease. A number of genome-wide association studies have provided important information on neurological disorders such as multiple sclerosis, with over
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Medication administration and management is a real problem in patients suffering from medical conditions associated with cognitive deficits. A recent study examined the experience of family members as they help take care of elder family members with Alzheimer’s disease. Compliance is an ongoing issue in medicine, particularly for elderly patients with medical conditions that cause
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In a 2017 study, researchers explored the association between single nucleotide polymorphisms of the C-reactive protein gene and age-related macular degeneration. The findings suggest that C-reactive protein does not cause macular degeneration. Associations have been drawn between high levels of the inflammatory biomarker C-reactive protein (CRP) and age-related macular degeneration (AMD) – deterioration of the
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A study published recently in the American Journal of Clinical Nutrition investigated whether a higher consumption of milk alternatives as opposed to cow milk will result in lower heights during childhood. A wealth of research evidence exists supporting the idea that height is a crucial measure of a child’s development and nutritional status. Relatedly, consuming
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A new study finds an association between the serum levels of trans-fatty acids and that of the inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and fibrinogen, suggesting that dietary trans-fatty acids may contribute to inflammation-related disorders such as diabetes mellitus and cardiovascular disease. Trans-unsaturated fatty acids (also known as trans-fatty acids or trans-fats)are unsaturated fatty acids
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With increasing awareness of how complex, damaging, and persistent brain injuries can be, researchers have been analyzing and improving the ways we diagnose damage to the brain. New methods of performing CT scans have outperformed previous ways and will be critical in improved treatment and diagnosis of trauma. Terrifying brain injuries seem all too common-
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Gonorrhea is one of the most common STI (sexually transmitted infections) worldwide. In 2016, the Global Antibiotic Research and Development Partnership (GARDP) was developed to address the concerns regarding the emergence of multidrug-resistant gonorrhea and the need for new treatments. Gonorrhea, caused by Neisseria gonorrheae bacteria is one of the most common STIs (sexually transmitted
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A recent study published in BMC Public Health determines whether Australian runners who participate in community-based physical activity are more satisfied with their physical health compared to the general population. Although the benefits of physical activity have been well-established, many people struggle to incorporate exercise into their daily routines. Community-based fitness events encourage not only
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New studies demonstrate that inhibiting the activity of angiopoietin-like 3 (ANGPTL3), a liver protein that regulates lipoprotein metabolism and inhibits lipoprotein lipase (LPL), could help lower the plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol as well as reduce the risk of atherosclerotic coronary artery disease.   It has been
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A recently published review in JAMA Pediatrics considers historical reasons and present implications of testing for respiratory tract infections in children. Respiratory tract infections (RTIs) in children are a major cost and burden to the healthcare system. These respiratory tract infections, like bronchiolitis, the common cold, and seasonal influenza, affect physician and nursing time, emergency
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