Month: August 2017

Scientists compared three anti-epileptic drugs including one branded Lamotrigine and two lamotrigine-generic drugs and found them to be bioequivalent. Now we know: branded and generic drugs can be substituted with confidence. It is estimated that nearly 80% prescriptions filled in the US are for generic drugs. The US Food and Drug Administration (FDA) requires that
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Scientists at the Center for Injury Research and Prevention at the Children’s Hospital of Philadelphia asked the question; “what is the association between attention-deficit/ hyperactivity disorder (ADHD) and car crashes involving young adult drivers, and does this vary by sex, licensing age, and/or being prescribed ADHD medication?” Car crashes are the leading cause of death
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In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms. Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound effects on
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A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer. Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with locally
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A meta-analysis combining results across studies assessed outcomes of tight versus standard glucose management on the prevention of onset and progression of end-stage kidney disease (ESKD) in diabetic patients. Study results suggest that diabetic patients who were under stringent glucose control have a comparable risk of kidney failure to those under standard glucose management. Diabetes
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Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection. Cervical cancer, caused by the human
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Chronic kidney disease is both a cause and consequence of hypertension. In patients with both conditions, accurate evaluation and a tailored treatment program are essential for successful hypertension management. Blood circulates through the body at a certain pressure within the arteries. This pressure changes depending on activity levels– elevating during exercise, to increase the blood
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence. Stress urinary incontinence, or
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The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS). The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence by
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Cardiovascular diseases are currently the leading cause of mortality worldwide. A group of researchers led by Jeffrey Cohen introduced a new method of preventing heart attacks using photosynthetic bacteria. According to the World Health Organization, cardiovascular diseases are the leading cause of mortality worldwide. Different strategies are being studied to improve
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A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence. Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
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Diabetic foot ulcers are one of the most common complications affecting diabetic patients. A recent review article outlines preventative measures that can decrease the odds of developing foot ulcers. Diabetic foot ulcers, especially on the bottom of the foot, are a common problem in diabetics. Up to 26.1 million diabetic patients worldwide are estimated to
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A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not. Triggered
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PET scanning revealed elevated translocator protein in several regions comprising the neurocircuitry of Obsessive Compulsive Disorder (OCD), indicating a pathogenic role for microglia in the neuropathogenesis of OCD. Though several Hollywood stars have been diagnosed with OCD, no one is better remembered for suffering from this debilitating condition than Howard Hughes of ‘The Aviator’. Characterized
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Childhood obesity in the United States has long been a multifaceted disorder that health professionals have struggled to battle effectively. Strategies that if implemented at an early enough age and applied consistently afterwards can lessen obese children’s current health problems and the multitude that can appear later in adulthood such as cardiovascular disease. An article
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A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron deficiency
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Cancer encompasses a range of diseases with varying mortality rates. A recent study has shown how cancer mortality rates have changed and influenced life expectancy over 30 years and have uncovered discrepancies in cancer control efforts between different populations. Cancer is predicted to become the primary cause of global morbidity and mortality, surpassing cardiovascular disease
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Researchers investigated the effect of age and proton pump inhibitors on aspirin-associated bleeding in cardiovascular patients. The study found that use of proton pump inhibitors reduces the risk and severity of bleeding in patients 75 and older. Though antiplatelet therapies such as aspirin are routinely prescribed for the prevention of recurring cardiovascular events in older
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